Flyers vs Sabres Picks, Odds & Best Bets: October 21, 2026

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Our PickBuffalo Sabres
Buffalo Sabres logo
Buffalo Sabres -1.5
+130Fanatics
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The Flyers roll into Buffalo and they cannot score. Philly has 14 goals in 10 games, it’s been outshot by 117, and now Travis Konecny and Owen Tippett are both on injured reserve. Wings and a Sabres win sounds like a Wednesday to me.

The Matchup

  • Philly can’t find the net. The Flyers are 1-6-3 with 14 goals. They scored one goal in three of their last five.
  • The shots aren’t close. Philadelphia averages about 21 shots a game and allows about 33.
  • Philly is banged up. Konecny and Tippett are on injured reserve, and Sean Couturier and Tyson Foerster are day-to-day.
  • Buffalo can score. The Sabres have 27 goals in nine games. Tage Thompson has five goals on 42 shots, and Jack Quinn has three goals in his last two. Rasmus Dahlin (upper body) says he thinks he’ll be ready, and Jason Zucker is on track to make his season debut.
  • Puck drop. 7:30 PM ET at KeyBank Center, on TNT, truTV and HBO Max.

The Goalies

Dan Vladar is confirmed for Philadelphia, at 88.9% through five.

Ukko-Pekka Luukkonen is confirmed for Buffalo after three straight starts, at 85.4% through six. Buffalo has allowed 34 goals on just 231 shots, and that’s the biggest reason this is only a lean.

The Number

The moneyline ran to -200, past the -190 I’d pay, so I’m moving to the puck line at plus money. Philly scores 1.4 goals a game, so a two-goal Buffalo win is a real outcome, not a long shot.

The honest case against: Buffalo’s goaltending has been leaky, and a one-goal game cashes the moneyline but loses this. It’s a Game Pick, a lean, and like every pick we post, it lands on the receipts page win or lose.

Bottom Line

Take the Sabres on the puck line (-1.5) at . Lean. Philly can’t score. Let’s go Buffalo.

Lines as posted Wednesday at 4:58 PM ET. Vladar and Luukkonen are confirmed.

Same-Game Parlay

If Buffalo wins by two, Tage Thompson is probably in on it. He has scored in five of nine games. Every leg needs the same night, so this is one position, not two bets.

Same-game parlay
Flyers at Sabres · Wednesday 7:30 PM ET
1Buffalo Sabres -1.5 (+128)FanDuel
2Tage Thompson anytime goal (+140)FanDuel

The angleThompson scores and Buffalo wins going away.

Build it at FanDuel →

FanDuel prices same-game parlays in its own builder, so there is no price here. Build the legs there and check the number before you place it.

Price: check your sportsbook for SGP pricing. Lines as posted Wednesday at 4:58 PM ET; confirm them before you build the ticket. This parlay is a Game Pick. Player props not available in all states.

Best Props for This Game

Bets beyond the side, from either team. Every one has a trend, a matchup and a real price behind it. These are Game Pick props, separate bets from our pick, so keep them small.

Tage Thompson over 3.5 shots on goal+110FanDuel

Buffalo’s volume shooter, at plus money.

  • Trend4 or more shots in 7 of 9 games: 4, 4, 9, 6, 6, 1, 1, 6 and 5
  • MatchupPhiladelphia allows about 33 shots a game

Bet it at FanDuel →

Tage Thompson anytime goal+140FanDuel

Five goals in nine games, against a goalie at 88.9%.

  • TrendScored in 5 of 9 games
  • MatchupVladar is at 88.9% through five

Bet it at FanDuel →

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