VS

USC vs Indiana: Hoosiers by 11 or More

COLLEGE FOOTBALL · WEEK 11 · PICK · SAT NOV 14 · 3:30 PM ET · CBS
SLATELINES PICKS 21+ · sportsbook links pay us a commission

Our edge: Indiana hasn't given up more than 23 points in a game all season, and USC ran for minus-18 yards in its last road game. The Hoosiers win this one going away. Our score: Indiana 27, USC 16.

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COMPARE ODDSBest price highlighted · 4:03 PM ET
OUR PICKSFanDuelFanaticsBetMGM
Indiana −10.5+110BEST+110+110

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01 · POINT SPREADOUR PICK

Indiana −10.5

Indiana −10.5: our chance it cashes49%51%Indiana −10.5  +110FanDuel›Our estimate. Not a guarantee.

Nobody scores on this defense

Indiana gives up 12.4 points and 75.6 rushing yards a game, and nobody has scored more than 23 on the Hoosiers all year. They have 32 sacks, and Tobi Osunsanmi has 10 of them. At Michigan, Indiana held the Wolverines to 57 rushing yards on 42 carries. Against Minnesota on Oct. 31, it allowed 215 total yards and 3 of 15 on third down.

Indiana has also been flagged only 38 times all season. This defense doesn’t hand you anything, and it has had two weeks to get ready for USC.

Points allowed per game
Indiana12.4
USC24.2
2026 season through Nov 8 (ESPN team stats)

USC on the road is a different team

Jayden Maiava has 2,524 passing yards with 20 touchdowns and five picks, and at home he’s dangerous. The last Big Ten road trip was a disaster. At Wisconsin on Oct. 24, USC ran 25 times for minus-18 yards, Maiava went 31 of 50 for 257 with two interceptions, and the Trojans lost 24-7.

On the other side, Josh Hoover has started all nine games for Indiana, with 19 touchdown passes and two picks. He hurt his right shoulder against Ohio State on Oct. 17, and Grant Wilson came in at halftime against Minnesota and went 9 of 17 for 156 yards and a touchdown. Curt Cignetti hasn’t said who starts. I don’t care, because this pick lives on the defense. Indiana also runs for 186.2 yards a game at 5.3 a carry, and USC gives up 124.8 on the ground. Our numbers have Indiana by 10. I’m going one more point and taking the plus money. Go Hoosiers.

Moneyline: who winsSPREAD IS THE BETTER BUY

You're paying −320 or worse just to pick the winner. We're going bigger: Indiana by 11 or more at +110.

Best price: −425 at BetMGMBetMGM
How this blows up on me

Indiana's offense stays stuck. The Hoosiers have scored 23 or fewer in four straight games, and two of those needed overtime. And USC beat Ohio State 30-18, the same team that beat Indiana in Bloomington. If Maiava gets clean pockets, this is a one-score game in the fourth quarter.

Shop the number

The safe number is −8.5. We're calling Indiana by 11 or more, so we're laying ten and a half and getting +110 for it.

−10.5+110FanDuel
02 · PARLAYSSAME GAME

Parlays

CRAZY BET3-Leg Same Game ParlaySGP
USC @ IU · SAT 3:30 PM
Indiana −10.5Alt spread+110
Georgia −20.5 ALT LINEAlt spread+144
Texas MLMoneyline+150
EST. ODDS+1181
Build this ticketFanDuel

This is the Crazy Bet. For fun, small money. All of our bold calls on one ticket comes out to roughly +1200 at the prices listed. Your book's parlay price may differ.

03 · LIVEIN-GAME

If this happens, tap that

Set before kickoff. Keep this open during the game. When one hits, tap it.

DON'T CHASEIf Indiana is up 7 late and the -10.5 looks shaky, don't buy another Indiana ticket to fix it. The ticket is already riding.

21+. One live bet per trigger. Live odds move fast, so check the price before you bet.

WHO YOU GOT?

Can USC score on this Indiana defense? Who you got? Tell me I'm wrong.

Tell me I'm wrong.

HoosiersTrojans