49ers vs Seahawks Picks, Odds & Best Bets: October 11, 2026

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Our PickSeattle Seahawks
Seattle Seahawks logo
Seattle Seahawks -3
-118FanDuel
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I’ll lay three with Seattle at home. Our preview had the Seahawks as the best team in the NFC by our preseason numbers, and the numbers make them closer to a six-point favorite. San Francisco is 4-0, though, and almost everyone is betting the 49ers. It’s a lean.

1.5
Points between our number and the board at half strength

The Number

Our preview had San Francisco at 10.1 wins and Seattle at 13. One point of spread for every win, plus three for the home team, makes this Seattle by 5.9. The board has Seattle by three. That’s 2.9 points of daylight on the Seahawks. We cut that gap in half, because a preseason number knows less in October than it thinks it does, which leaves 1.5 points. That’s a small edge, so it’s a lean.

The line opened at three and is three and a half at some shops, with more than eight in ten bets and nearly nine in ten dollars on San Francisco. Get three if you can.

The Matchup

The 49ers will likely be without Nick Bosa, and Mike Evans is dealing with a rib injury. Without Bosa, the pass rush gets a lot easier for the Seahawks, and Jaxon Smith-Njigba leads the league with 481 receiving yards. He’s cleared 94 yards in two of his last three. George Kittle has topped 55 receiving yards in all three of his last games, so San Francisco will move the ball too.

Bottom Line

Take Seattle minus three at . Lean. Our numbers make Seattle about a six-point favorite, and the board asks three. San Francisco’s 4-0 start and the public money keep it a lean.

Same-Game Parlay

Three legs, one read: Seattle covers because Smith-Njigba has a big day against a pass rush without Bosa, even with Kittle getting his. Every leg needs the same game, so this is one position, not three bets.

Same-game parlay
49ers at Seahawks · Sunday 4:25 PM ET
1Seattle Seahawks -3FanDuel
2Jaxon Smith-Njigba over 94.5 receiving yards (-114)FanDuel
3George Kittle over 55.5 receiving yards (-110)FanDuel

The angleSmith-Njigba runs wild without Bosa in the lineup and Seattle covers.

Build it at FanDuel →

FanDuel prices same-game parlays in its own builder, so there is no price here. Build the legs there and check the number before you place it.

Price: check your sportsbook for SGP pricing. Lines as posted Friday at 5:00 PM ET; confirm them before you build the ticket. Player props not available in all states.

Best Props for This Game

Jaxon Smith-Njigba over 94.5 receiving yards−114FanDuel

He leads the league in receiving yards and has cleared this in two of his last three.

  • Trend2 of 3: 155, 128 and 76
  • MatchupNick Bosa is unlikely to play

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George Kittle over 55.5 receiving yards−110FanDuel

He’s cleared this in all three of his last games.

  • Trend3 of 3: 80, 82 and 70
  • MatchupEvans’ rib injury could push more targets his way

Bet it at FanDuel →

Prices checked Friday at 5:00 PM ET. Prop prices move fast, so confirm them before you bet. Player props not available in all states.

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