Lions vs Cardinals Picks, Odds & Best Bets: October 11, 2026

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Our PickArizona Cardinals
Arizona Cardinals logo
Arizona Cardinals +5.5
-110Fanatics
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I’ll take Arizona plus five and a half at home. Our numbers make Detroit less than a two-point favorite, and this has the highest total on the board, which usually means more chances for the underdog to get back in it. It’s a lean.

2.0
Points between our number and the board at half strength

The Number

Our preview had Detroit at 10 wins and Arizona at 5.4. One point of spread for every win, plus three for the home team, makes this Detroit by 1.6. The board has Detroit by five and a half. That’s 3.9 points of daylight on the Cardinals. We cut that gap in half, because a preseason number knows less in October than it thinks it does, which leaves 2 points. That’s a small edge, so it’s a lean.

The line opened at five and a half on most boards and hasn’t moved, and the bets are close to even.

The Matchup

The Lions throw a lot. Jared Goff has completed at least 25 passes in each of his last three games and has 38 or more attempts in three of four. Amon-Ra St. Brown has caught at least eight passes in two of his last three. But a team throwing that much also gives its opponent possessions, and the Cardinals are at home. Detroit has ruled out guard Ben Bartch, center Cade Mays, corner Rock Ya-Sin and safety Brian Branch, and Arizona’s Jeremiyah Love is off the injury report.

Bottom Line

Take Arizona plus five and a half at . Lean. Our numbers make Detroit a small road favorite, and the board asks five and a half. A high-scoring game helps the team getting points, and it’s a lean.

Same-Game Parlay

Three legs, one read: Detroit throws all day, and Arizona stays within the number in a high-scoring game. Every leg needs the same game, so this is one position, not three bets.

Same-game parlay
Lions at Cardinals · Sunday 4:25 PM ET
1Arizona Cardinals +5.5FanDuel
2Jared Goff over 24.5 completions (-115)FanDuel
3Amon-Ra St. Brown over 7.5 receptions (-103)FanDuel

The angleGoff throws a lot, St. Brown catches a lot, and Arizona stays inside the number.

Build it at FanDuel →

FanDuel prices same-game parlays in its own builder, so there is no price here. Build the legs there and check the number before you place it.

Price: check your sportsbook for SGP pricing. Lines as posted Friday at 5:00 PM ET; confirm them before you build the ticket. Player props not available in all states.

Best Props for This Game

Jared Goff over 24.5 completions−115FanDuel

He’s cleared this in all three of his last games.

  • Trend3 of 3: 26, 25 and 32
  • MatchupThe highest total on the board, and Detroit throws a lot

Bet it at FanDuel →

Jared Goff over 280.5 passing yards−114FanDuel

He’s cleared this in two of his last three.

  • Trend2 of 3: 327, 269 and 412
  • Matchup38 or more attempts in three of four games

Bet it at FanDuel →

Prices checked Friday at 5:00 PM ET. Prop prices move fast, so confirm them before you bet. Player props not available in all states.

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